Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
| Author | |
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| Abstract | :
DNA-PK and PARP inhibitors sensitize cancer cells to chemo- and radiotherapy. ETS transcription factors (EWS-FLI1) have been described as biomarkers for PARP-inhibitor sensitivity. Sensitivity to single agent PARP inhibitors has so far been limited to homologous recombination repair (HRR) deficient tumors, exploiting synthetic lethality. |
| Year of Publication | :
2017
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| Journal | :
Oncotarget
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| Volume | :
8
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| Issue | :
69
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| Number of Pages | :
113418-113430
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| Date Published | :
2017
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| DOI | :
10.18632/oncotarget.21300
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| Short Title | :
Oncotarget
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