alpha-1-antichymotrypsin interaction with A beta (1-40) inhibits fibril formation but does not affect the peptide toxicity.
Author | |
---|---|
Abstract | :
Recent studies have shown that senile plaque-associated or glial-derived proteins can prevent fibril formation of beta-amyloid peptide (A beta), while increasing the neurotoxicity of the latter (in the case of glutamine synthetase, apolipoprotein J or thrombin). alpha-1-Antichymotrypsin (ACT) is a glial-derived protein associated with senile plaques in the Alzheimer's brain. In this report we show that ACT, a minor protein component of beta-amyloid deposits, is able to inhibit A beta (1-40) aggregation into fibrils, but unable to modulate the toxicity of A beta (1-40) in primary rat hippocampal cell cultures. These results are discussed in terms of the potential role of glial-derived proteins on A beta aggregation and neurotoxicity. |
Year of Publication | :
1996
|
Journal | :
Neuroscience letters
|
Volume | :
211
|
Issue | :
1
|
Number of Pages | :
45-8
|
Date Published | :
1996
|
ISSN Number | :
0304-3940
|
URL | :
https://linkinghub.elsevier.com/retrieve/pii/0304394096127178
|
DOI | :
10.1016/0304-3940(96)12717-8
|
Short Title | :
Neurosci Lett
|
Download citation |