The author investigated the influence of dispositional empathy on alcohol-related aggression in men and women. Participants were 204 (111 men, 93 women) healthy social drinkers, 21-35 years old. Dispositional empathy was measured with the Interpersonal Reactivity Index. Following the consumption of either an alcoholic or a placebo beverage, participants were tested on a modified version of the Taylor Aggression Paradigm in which mild electric shocks were received from, and administered to, a fictitious opponent during a competitive task. Alcohol increased aggression for persons (particularly men) with lower, as opposed to higher, levels of empathy. Men with lower empathy levels exhibited the most aggression followed by men with higher empathy levels. Women displayed the least aggression regardless of their empathy levels.