Sotatercept with long-term extension for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes: a phase 2, dose-ranging trial.
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| Abstract | :
Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. |
| Year of Publication | :
2018
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| Journal | :
The Lancet. Haematology
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| Date Published | :
2018
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| URL | :
http://linkinghub.elsevier.com/retrieve/pii/S2352-3026(18)30002-4
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| DOI | :
10.1016/S2352-3026(18)30002-4
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| Short Title | :
Lancet Haematol
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