Emerging Potential Benefits of Modulating NAD<sup>+</sup> Metabolism in Cardiovascular Disease.
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Abstract | :
Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes including sirtuins and poly(ADP-ribose) polymerases (PARPs) that regulate post-translational modifications, DNA damage responses, and calcium signaling. Recent research indicates that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors including nicotinamide riboside (NR) that boost or replete the NAD+ metabolome may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure related cardiac remodeling, ischemic/reperfusion injury, and arrhythmias. In addition, alternative NAD+ boosting-strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease are surveyed. |
Year of Publication | :
2017
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Journal | :
American journal of physiology. Heart and circulatory physiology
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Date Published | :
2017
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ISSN Number | :
0363-6135
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URL | :
http://www.physiology.org/doi/abs/10.1152/ajpheart.00409.2017?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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DOI | :
10.1152/ajpheart.00409.2017
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Short Title | :
Am J Physiol Heart Circ Physiol
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